How to Treat Mosquito Bites: Our Body’s Histamine Response

Camping season is here… which means s’mores, swims, and… swarms of mosquitos (and their bites, unfortunately). So if you’re wondering how to treat mosquito bites, then you’ll want to keep reading.

What is a mosquito bite, anyway?

When a mosquito bites, it injects a tiny bit of saliva into the skin. This saliva contains proteins that stop your blood from clotting, but it also triggers your immune system to respond. The body sees the saliva as a threat and releases histamine, which causes the familiar (and appropriate) swelling, redness, and itching.

In most children, the reaction is mild. But for children with eczema, asthma, allergies, or gut inflammation, the reaction can be way more intense. Instead of a small bump, they get a hot, swollen welt that lasts for days—sometimes even needing steroid creams or antibiotics if it becomes infected.

The Impact of Histamine

As our integrative pharmacist, Deb, refers to it, think of histamine like a bouncer for your body. Histamine is stored in immune cells called mast cells and is released when your body senses something irritating or a potential threat (like an insect bite or allergen).

Histamine helps “hustle out” whatever’s bothering you (which is a good thing!). However, in kids with eczema, asthma, allergies, or gut inflammation, their immune system is more sensitive, and so the histamine response can be way too enthusiastic.

Too much histamine = swelling, redness, itching, and a nervous system that’s now on high alert.

What Triggers Histamine Release?

It’s not just the bite itself. Heat, stress (physical and emotional), and even poor gut health can cause histamine to surge.

Summer = the perfect storm:


☀️ High temps
🦟 Bug bites
🍦 Sugar
🚗 Travel stress + less sleep

All of these can lead to bigger, more intense reactions.

Natural Remedies to Prevent Intense Reactions & Treat Mosquito Bites

🍃 Reduce histamine naturally 🍃

Take HKHM Hist-Assist daily during peak summer months. Think of it as Nature’s Antihistamine.

✔️ Quercetin to support healthy histamine levels
✔️ Bromelain to enhance quercetin absorption and support mucosal tissue
✔️ Stinging nettles leaf to balance immune overreaction
✔️ N-acetyl cysteine (NAC) to clear airways and reduce mucus thickness

Availabe in both capsule and chewable forms.

hist-assist for treating mosquito bites
hist-assist jr. to treat mostquito bites

🧴 Calm the skin immediately after a bite 🧴

Spray the affected area with Briotech Topical Skin Spray to reduce inflammation and fight off any microbes.

✔️ Pure Hypochlorous Acid (HOCl), a compound your body naturally produces to fight irritation
✔️ Antibacterialantiviral, and antifungal
✔️ All naturalvegan, and organic (and free of oil, alchohol, and additives)

Dab on Organic Manuka Honey Cream to soothe the area and support healing.

✔️ Non-greasy balm rich in emollients
✔️ Organic tree nut-free oils and beeswax
✔️ Will not burn or sting the skin (dermatologist tested and approved!)

YoRo Manuka Skin Cream to treat mosquito bites

These tools can help your child bounce back from bites faster and reduce how big their reaction is in the first place.

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What If You Could Break Your Child's Sick Cycle?

Discover 7 Steps to Heal and
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The Healthy Kids, Happy Moms Companion Course is a physician-led, parent-centered, time-tested online course that includes assessments, workbooks, recipes, and illness-specific recommendations.

Become a Patient

 Dr. Kilbane’s private practice, Infinite Health, is based in Charlotte, North Carolina. She is currently accepting new patients

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What You Get With The Eczema Jump Start Guide:

Dr. Kilbane’s approach is universal and can be used by both children and adults who have eczema. Here’s what’s included: